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- Title
Effects of Gamma Radiation on the Expression of Interferon Type I Stimulated Genes in Antigen Presenting Cells.
- Authors
Navarro-Lopez; Vazquez-Hernandez; Montalvo-Corral; Garibay-Escobar; Silva-Campa
- Abstract
Antigen Presenting Cells (APCs) play a crucial role in the antiviral response by producing Type I Interferons (IFN-I). While ionizing radiation’s immunomodulatory role is known, its effects and applications in APCs are still being studied. We evaluated the impact of 1.5, 2, 12.5, and 30 Gy on IFN-I stimulated genes (ISGs) expression in monocyte-derived dendritic cells using RT-qPCR. Overexpression of Interferon Regulatory Factor 3 occurred at 2 (P = 0.028) and 12.5 Gy (P = 0.046), and Tripartite Motif Containing 21 at 1.5 and 2 Gy (P = 0.037 for both). A tendency towards increased alpha interferon expression was observed at 2 and 12.5 Gy (P = 0.054 for both). The ISG expression alterations prompt further study of a possible promotion of the antiviral state in other APCs.
- Publication
Veterinaria México OA, 2024, Vol 11, p46
- ISSN
2448-6760
- Publication type
Article
- DOI
10.22201/fmvz.24486760e.2024.1305