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- Title
EP01.32: Brain signal for spontaneous onset of labour at term: a CSF proteomics study.
- Authors
Warintaksa, P.; Romero, R.; Weeraphan, J.; Limpiti, T.; Sangkum, L.; Sombatthaveekul, P.; Homthain, T.; Keesakul, C.; Kotchompoo, K.; Chiangjong, W.; Chaemsaithong, P.
- Abstract
This article, titled "EP01.32: Brain signal for spontaneous onset of labour at term: a CSF proteomics study," explores the brain signal for the spontaneous onset of labor in women at term gestation. The study involved 10 women, with 5 experiencing spontaneous labor and 5 without labor onset. The researchers analyzed cerebrospinal fluid (CSF) proteomics profiles using mass spectrometry and protein bioinformatic analyses. They found that 12 CSF protein analytes were more abundant in women with spontaneous labor, with the most upregulated protein being centrosome-associated protein ALMS1. The proteins changing with labor were associated with biological processes such as protein phosphorylation, insulin-growth factor transport, lipid remodeling, and platelet degranulation. The study suggests that the CSF proteome increases during labor and that intersecting the maternal plasma and CSF proteome could potentially identify biomarkers for diagnosing labor.
- Subjects
CEREBROSPINAL fluid examination; MASS spectrometry; CESAREAN section; PROTEIN-protein interactions; PROTEIN analysis
- Publication
Ultrasound in Obstetrics & Gynecology, 2024, Vol 64, p115
- ISSN
0960-7692
- Publication type
Article
- DOI
10.1002/uog.28046