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- Title
Cell type-specific polygenic burden modulates exercise effects in schizophrenia patients: further evidence on volumes of hippocampal subfields.
- Authors
Papiol, Sergi; Roell, Lukas; Maurus, Isabel; Hirjak, Dusan; Keeser, Daniel; Schmitt, Andrea; Meyer-Lindenberg, Andreas; Falkai, Peter
- Abstract
This article discusses the potential benefits of exercise as an adjunct therapy for schizophrenia patients. While current treatment options for schizophrenia have limited efficacy, exercise has shown promise in improving symptoms such as cognitive deficits and negative symptoms. Previous studies have suggested that aerobic exercise can increase hippocampal volume, which aligns with findings in schizophrenia patients. However, not all patients respond positively to the same type of physical activity, and recent research has indicated that the polygenic burden associated with certain cell types may modulate the effects of exercise on hippocampal subfield volumes. This study analyzed the effects of polygenic scores on a cohort of schizophrenia patients undergoing aerobic endurance training or flexibility, strengthening, and balance training. The results suggest that the polygenic burden associated with oligodendrocyte precursor cells may influence the volume changes in certain hippocampal subfields after exercise intervention. However, further research with larger cohorts is needed to confirm these findings.
- Subjects
GENETIC risk score; EXERCISE physiology; DENTATE gyrus; PYRAMIDAL neurons; AEROBIC exercises
- Publication
European Archives of Psychiatry & Clinical Neuroscience, 2024, Vol 274, Issue 6, p1241
- ISSN
0940-1334
- Publication type
Editorial
- DOI
10.1007/s00406-024-01841-9