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- Title
The Effect of Ascorbic Acid on Hepatic Ischaemia–Reperfusion Injury in Wistar Rats: An Experimental Study.
- Authors
Ximenes, Jorge Luiz Saraiva; Rocha-Filho, Joel Avancini; Galvão, Flavio Henrique Ferreira; Lanchotte, Cinthia; Kubrusly, Marcia Saldanha; Leitão, Regina Maria Cubero; Jukemura, Jose; Moscoso, Agustin Vintimilla; Abdo, Emilio Elias; D'Albuquerque, Luiz Augusto Carneiro; Figueira, Estela Regina Ramos
- Abstract
Liver ischaemia–reperfusion (IR) during hepatic surgeries can lead to liver cell death via oxidative stress and the activation of immune cells, the release of cytokines, and damage-associated molecular patterns. Ascorbic acid has been shown to confer potential protective effects against IR injury, mainly due to its antioxidant properties. This study evaluated the effect of ascorbic acid infusion at different time points during hepatic IR in rats. Thirty-six male Wistar rats were divided into control and experimental groups that received the same total ascorbic acid dose at three different infusion times: before ischaemia, before reperfusion, or before both ischaemia and reperfusion. All of the animals experienced hepatic IR injury. We measured the hepatic enzymes, cytokines, and portal blood flow. Animals receiving ascorbic acid before both ischaemia and reperfusion had lower liver enzyme levels, reduced inflammation, and better portal venous flow than other animals. Divided doses of ascorbic acid before IR may be beneficial for reducing liver injury associated with IR.
- Subjects
VITAMIN C; LIVER cells; LABORATORY rats; LIVER enzymes; BLOOD flow; REPERFUSION
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 16, p8833
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25168833