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- Title
Vasoactive Intestinal Peptide Regulates Embryonic Growth Through the Action of Activity-dependent Neurotrophic Factor.
- Authors
HILL, JOANNA M.; GLAZNER, GORDON W.; LEE, SUSAN J.; GOZES, ILLANA; GRESSENS, PIERRE; BRENNEMAN, DOUGLAS E.
- Abstract
A bstract: Activity-dependent neurotrophic factor is a potent, neuroprotective protein released from astroglia by VIP and accounts in part for the neuroprotective properties of this neuropeptide. The growth-regulatory actions of VIP during embryogenesis may also occur indirectly through the release of activity-dependent neurotrophic factor. Whole cultured day-9 mouse embryos treated with activity-dependent neurotrophic factor (10−13 M) for 4 hr grew 3.1 somites, compared with 1.6 somites in control embryos. Treated embryos appeared morphologically normal and exhibited significant increases in cross-sectional area, protein, and DNA content and bromodeoxyuridine incorporation. Anti-activity-dependent neurotrophic factor significantly inhibited growth. Co-treatment of embryos with anti-activity-dependent neurotrophic factor inhibited VIP-stimulated growth; however, anti-VIP did not inhibit activity-dependent neurotrophic factor-induced growth. These data indicate that an activity-dependent neurotrophic factor-like substance is an endogenous embryonic growth factor and that VIP-regulated growth occurs, at least in part, through activity-dependent neurotrophic factor.
- Publication
Annals of the New York Academy of Sciences, 1999, Vol 897, Issue 1, p92
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.1999.tb07881.x