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- Title
The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells.
- Authors
Dartois, Véronique
- Abstract
For the successful treatment of pulmonary tuberculosis, drugs need to penetrate complex lung lesions and permeate the mycobacterial cell wall in order to reach their intracellular targets. However, most currently used anti-tuberculosis drugs were introduced into clinical use without considering the pharmacokinetic and pharmacodynamic properties that influence drug distribution, and this has contributed to the long duration and limited success of current therapies. In this Progress article, I describe new methods to quantify and image drug distribution in infected lung tissue and in mycobacterial cells, and I explore how this technology could be used to design optimized multidrug regimens.
- Subjects
TUBERCULOSIS treatment; BACTERIAL cell walls; MULTIDRUG-resistant tuberculosis; MYCOBACTERIUM tuberculosis; PHARMACOKINETICS
- Publication
Nature Reviews Microbiology, 2014, Vol 12, Issue 3, p159
- ISSN
1740-1526
- Publication type
Article
- DOI
10.1038/nrmicro3200