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- Title
The role of xanthine dioxygenase in the biosynthetic pathway of 2-aza-8-oxohypoxanthine of Lepista sordida.
- Authors
Mihaya Kotajima; Jae-Hoon Choi; Tomohiro Suzuki; Jing Wu; Hirofumi Hirai; Nelson, David C.; Hitoshi Ouchi; Makoto Inai; Hideo Dohra; Hirokazu Kawagishi
- Abstract
2-Azahypoxanthine (AHX) and 2-aza-8-oxohypoxanthine (AOH), discovered as causal substances of fairy rings are known to be endogenous in the fairy ring-forming Lepista sordida. In this study, we showed that xanthine dioxygenase, an a-ketoglutarate-dependent dioxygenase, might catalyze the conversion of AHX to AOH in the fungus. Furthermore, this enzyme is the first reported molybdopterin-independent protein of hypoxanthine metabolism.
- Subjects
XANTHINE; PROTEIN metabolism; DIOXYGENASES
- Publication
Bioscience, Biotechnology & Biochemistry, 2023, Vol 87, Issue 4, p420
- ISSN
0916-8451
- Publication type
Article
- DOI
10.1093/bbb/zbad005