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- Title
Ribosomal Incorporation of Aromatic Oligoamides as Peptide Sidechain Appendages.
- Authors
Tsiamantas, Christos; Kwon, Sunbum; Rogers, Joseph M.; Douat, Céline; Huc, Ivan; Suga, Hiroaki
- Abstract
Derivatives of 4‐aminomethyl‐l‐phenylalanine with aromatic oligoamide foldamers as sidechain appendages were successfully charged on tRNA by means of flexizymes. Their subsequent incorporation both at the C‐terminus of, and within, peptide sequences by the ribosome, was demonstrated. These results expand the registry of chemical structures tolerated by the ribosome to sidechains significantly larger and more structurally defined than previously demonstrated.
- Subjects
AMINO acid sequence; CHEMICAL structure; TRANSFER RNA; RIBOSOMES
- Publication
Angewandte Chemie, 2020, Vol 132, Issue 12, p4890
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201914654