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- Title
Syngas‐Free Highly Regioselective Rhodium‐Catalyzed Transfer Hydroformylation of Alkynes to α,β‐Unsaturated Aldehydes.
- Authors
Tan, Guangying; Wu, Yimin; Shi, Yang; You, Jingsong
- Abstract
The hydroformylation of alkynes is a fundamental and important reaction in both academic research and industry. Conventional methods focus on the conversion of alkynes, CO, and H2 into α,β‐unsaturated aldehydes, but they often suffer from problems associated with operation, regioselectivity, and chemoselectivity. Herein, we disclose an operationally simple, mild, and syngas‐free rhodium‐catalyzed reaction for the hydroformylation of alkynes via formyl and hydride transfer from an alkyl aldehyde. This synthetic method uses inexpensive and easy‐to‐handle n‐butyraldehyde to overcome the challenge posed by the use of syngas in traditional approaches and employs a commercially available catalyst and ligand to transform a broad range of internal alkynes, especially alkynyl‐containing complex molecules, into versatile stereodefined α,β‐unsaturated aldehydes with excellent chemo‐, regio‐, and stereoselectivity.
- Subjects
SYNTHESIS gas; RHODIUM; HYDROFORMYLATION; ALKYNES; ALDEHYDES
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 22, p7518
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201902553