We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Enantioselective Synthesis of Biaryl Atropisomers by Pd‐Catalyzed C−H Olefination using Chiral Spiro Phosphoric Acid Ligands.
- Authors
Luo, Jun; Zhang, Tao; Wang, Lei; Liao, Gang; Yao, Qi‐Jun; Wu, Yong‐Jie; Zhan, Bei‐Bei; Lan, Yu; Lin, Xu‐Feng; Shi, Bing‐Feng
- Abstract
The discovery of proper ligands to simultaneously modulate the reactivity and effectively control the stereoselectivity is a central topic in the field of enantioselective C−H activation. Herein, we reported the synthesis of axially chiral biaryls by Pd‐catalyzed atroposelective C−H olefination. A novel chiral spiro phosphoric acid, STRIP, was identified as a superior ligand for this transformation. A broad range of axially chiral quinoline derivatives were synthesized in good yields with excellent enantioselectivities (up to 98 % ee). Density functional theory was used to gain a theoretical understanding of the enantioselectivities in this reaction.
- Subjects
PALLADIUM catalysts; STEREOSELECTIVE reactions; ATROPISOMERS; ENANTIOSELECTIVE catalysis; OLEFINATION reactions; CARBON-hydrogen bonds
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 20, p6780
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201902126