We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Iridium‐Catalyzed Reductive Alkylations of Secondary Amides.
- Authors
Ou, Wei; Han, Feng; Hu, Xiu‐Ning; Chen, Hang; Huang, Pei‐Qiang
- Abstract
Abstract: Reported herein is the first direct, metal‐catalyzed reductive functionalization of secondary amides to give functionalized amines and heterocycles. The method is shown to have exceptionally broad scope with respect to suitable nucleophiles, which cover both hard and soft C nucleophiles as well as a P nucleophile. The reaction exhibits good chemoselectivity and tolerates several sensitive functional groups.
- Subjects
IRIDIUM catalysts; ALKYLATION; AMIDES; METAL catalysts; HETEROCYCLIC compounds; NUCLEOPHILES
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 35, p11524
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201806747