We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Bacterial Alkaloids Prevent Amoebal Predation.
- Authors
Klapper, Martin; Götze, Sebastian; Barnett, Robert; Willing, Karsten; Stallforth, Pierre
- Abstract
Bacterial defense mechanisms have evolved to protect bacteria against predation by nematodes, predatory bacteria, or amoebae. We identified novel bacterial alkaloids (pyreudiones A-D) that protect the producer, Pseudomonas fluorescens HKI0770, against amoebal predation. Isolation, structure elucidation, total synthesis, and a proposed biosynthetic pathway for these structures are presented. The generation of P. fluorescens gene-deletion mutants unable to produce pyreudiones rendered the bacterium edible to a variety of soil-dwelling amoebae.
- Subjects
ALKALOIDS; NEMATODES; PSEUDOMONAS fluorescens; AMOEBIDA; PREDATION; BACTERIA
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 31, p9090
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201603312