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- Title
Iridium-Catalyzed Enantioselective Hydroalkynylation of Enamides for the Synthesis of Homopropargyl Amides.
- Authors
Bai, Xiao ‐ Yan; Wang, Zi ‐ Xuan; Li, Bi ‐ Jie
- Abstract
Reported is an iridium-catalyzed asymmetric hydroalkynylation of enamides with terminal alkynes. The reaction occurs regioselectively at the β-position of an enamide to produce homopropargyl amides. Good to high enantioselectivity was observed with an iridium complex ligated by a chiral bis(phosphine) ligand. This method provides a straightforward route to synthesize chiral homopropargyl amides with a stereocenter β to the amide.
- Subjects
IRIDIUM catalysts; ENANTIOSELECTIVE catalysis; AMIDE synthesis; AMIDES; ALKYNES; ALKYNE synthesis; CHEMICAL reactions
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 31, p9153
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201601792