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- Title
Revisiting an Inverse Dose-Fractionation Effect of Ionizing Radiation Exposure for Ischemic Heart Disease: Insights from Recent Studies.
- Authors
Zablotska, Lydia B.; Little, Mark P.; Hamada, Nobuyuki
- Abstract
Over the last two decades, there has been emerging evidence suggesting that ionizing radiation exposures could be associated with elevated risks of cardiovascular disease (CVD), particularly ischemic heart disease (IHD). Excess CVD risks have been observed in a number of exposed groups, with generally similar risk estimates both at low and high radiation doses and dose rates. In 2014, we reported for the first time significantly higher risks of IHD mortality when radiation doses were delivered over a protracted period of time (an inverse dose-fractionation effect) in the Canadian Fluoroscopy Cohort Study. Here we review the current evidence on the dose-fractionation effect of radiation exposure, discuss potential implication for radiation protection policies and suggest further directions for research in this area.
- Subjects
MYOCARDIAL ischemia; CORONARY disease; RADIATION protection; RADIATION exposure; DOSE fractionation; IONIZING radiation; RADIATION doses
- Publication
Radiation Research, 2024, Vol 201, Issue 7, p80
- ISSN
0033-7587
- Publication type
Article
- DOI
10.1667/RADE-00230.1