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- Title
A Dynamic Protocol to Explore NLRP3 Inflammasome Activation in Cerebral Organoids.
- Authors
El Soufi El Sabbagh, Dana; Attisano, Liliana; Andreazza, Ana Cristina; Machado, Alencar Kolinski
- Abstract
The NLRP3 inflammasome plays a crucial role in the inflammatory response, reacting to pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). This response is essential for combating infections and restoring tissue homeostasis. However, chronic activation can lead to detrimental effects, particularly in neuropsychiatric and neurodegenerative diseases. Our study seeks to provide a method to effectively measure the NLRP3 inflammasome's activation within cerebral organoids (COs), providing insights into the underlying pathophysiology of these conditions and enabling future studies to investigate the development of targeted therapies.
- Subjects
NLRP3 protein; INFLAMMASOMES; ORGANOIDS; NEURODEGENERATION; INFLAMMATION; HOMEOSTASIS
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 12, p6335
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25126335