We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients.
- Authors
Ryan JL; Heckler CE; Roscoe JA; Dakhil SR; Kirshner J; Flynn PJ; Hickok JT; Morrow GR; Ryan, Julie L; Heckler, Charles E; Roscoe, Joseph A; Dakhil, Shaker R; Kirshner, Jeffrey; Flynn, Patrick J; Hickok, Jane T; Morrow, Gary R
- Abstract
<bold>Purpose: </bold>Despite the widespread use of antiemetics, nausea continues to be reported by over 70% of patients receiving chemotherapy.<bold>Methods: </bold>In this double blind, multicenter trial, we randomly assigned 744 cancer patients to four arms: 1) placebo, 2) 0.5 g ginger, 3) 1.0 g ginger, or 4) 1.5 g ginger. Nausea occurrence and severity were assessed at a baseline cycle and the two following cycles during which patients were taking their assigned study medication. All patients received a 5-HT(3) receptor antagonist antiemetic on Day 1 of all cycles. Patients took three capsules of ginger (250 mg) or placebo twice daily for 6 days starting 3 days before the first day of chemotherapy. Patients reported the severity of nausea on a 7-point rating scale ("1" = "Not at all Nauseated" and "7" = "Extremely Nauseated") for Days 1-4 of each cycle. The primary outcomes were to determine the dose and efficacy of ginger at reducing the severity of chemotherapy-induced nausea on Day 1 of chemotherapy.<bold>Results: </bold>A total of 576 patients were included in final analysis (91% female, mean age = 53). Mixed model analyses demonstrated that all doses of ginger significantly reduced acute nausea severity compared to placebo on Day 1 of chemotherapy (p = 0.003). The largest reduction in nausea intensity occurred with 0.5 g and 1.0 g of ginger (p = 0.017 and p = 0.036, respectively). Anticipatory nausea was a key factor in acute chemotherapy-induced nausea (p < 0.0001).<bold>Conclusions: </bold>Ginger supplementation at a daily dose of 0.5 g-1.0 g significantly aids in reduction of the severity of acute chemotherapy-induced nausea in adult cancer patients.
- Publication
Supportive Care in Cancer, 2012, Vol 20, Issue 7, p1479
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-011-1236-3