We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Burden of Candida-related vascular graft infection: a nested-case control study.
- Authors
Caulier, Thomas; Senneville, Eric; Sobocinski, Jonathan; Leroy, Olivier; Patoz, Pierre; Blondiaux, Nicolas; Georges, Hugues; Pierre-Yves, Delannoy; d'Elia, PierVito; Robineau, Olivier
- Abstract
Purpose: We aimed to assess risk factors of candida-related Vascular Graft Infections (VGIs). Methods: We did a case–control study (1:4) matched by age and year of infection, nested in a cohort of patient with a history of VGIs. Cases were defined by a positive culture for Candida spp. in biological samples and controls were defined by a positive culture for bacterial strains only in biological samples. Risk factors for Candida-related VGIs were investigated using multivariate logistic regression. Mortality were compared using survival analysis. Results: 16 Candida-related VGIs were matched to 64 bacterial-related VGIs. The two groups were comparable regarding medical history and clinical presentation. Candida-related VGIs were associated with bacterial strains in 88% (14/16). Gas/fluid-containing collection on abdominal CT scan and the presence of an aortic endoprosthesis were risk factors for Candidaspp.-related VGIs [RRa 10.43 [1.81–60.21] p = 0.009 RRa and 6.46 [1.17–35.73] p = 0.03, respectively]. Candida-related VGIs were associated with a higher mortality when compared to bacterial-related VGIs (p = 0.002). Conclusions: Candida-related VGIs are severe. Early markers of Candidaspp. infection are needed to improve their outcome. The suspicion of aortic endoprosthesis infection may necessitate probabilistic treatment with antifungal agents.
- Subjects
FRANCE; AORTA surgery; BACTERIAL disease risk factors; BACTERIAL disease complications; RISK assessment; STATISTICAL models; PROSTHESIS-related infections; TRANSPLANTATION of organs, tissues, etc.; MICROBIAL sensitivity tests; T-test (Statistics); MULTIPLE regression analysis; COMPUTED tomography; FISHER exact test; REVASCULARIZATION (Surgery); SYMPTOMS; BLOOD vessel prosthesis; DESCRIPTIVE statistics; MANN Whitney U Test; CHI-squared test; MULTIVARIATE analysis; RELATIVE medical risk; HOSPITAL mortality; TREATMENT effectiveness; KAPLAN-Meier estimator; REINFECTION; CASE-control method; STATISTICS; CANDIDIASIS; SURVIVAL analysis (Biometry); COMPARATIVE studies; DATA analysis software; CONFIDENCE intervals; BACTERIAL diseases; ABDOMINAL radiography; OVERALL survival; DISEASE risk factors; DISEASE complications
- Publication
Infection, 2024, Vol 52, Issue 3, p1153
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-023-02172-y