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- Title
Age, COVID-19-like symptoms and SARS-CoV-2 seropositivity profiles after the first wave of the pandemic in France.
- Authors
Carrat, Fabrice; Lapidus, Nathanael; Ninove, Laetitia; Blanché, Hélène; Rahib, Delphine; Saba Villarroel, Paola Mariela; Touvier, Mathilde; Severi, Gianluca; Zins, Marie; Deleuze, Jean-François; de Lamballerie, Xavier; for the SAPRIS-SERO study group; Ancel, Pierre-Yves; Charles, Marie-Aline; Bajos, Nathalie; Jusot, Florence; Martin, Claude; Meyer, Laurence; Pailhé, Ariane; Rouquette, Alexandra
- Abstract
Background: The interplay between age and symptoms intensity on antibody response to SARS-CoV-2 infection has not been studied in a general population setting. Methods: We explored the serologic profile of anti-SARS-CoV-2 antibodies after the first wave of the pandemic, by assessing IgG against the spike protein (ELISA-S), IgG against the nucleocapsid protein (ELISA-NP) and neutralizing antibodies (SN) in 82,126 adults from a French population-based multi-cohort study. Results: ELISA-S positivity was increased in 30- to 49-year-old adults (8.5%) compared to other age groups (5.6% in 20- to 29-year-olds, 2.8% in ≥ 50-year-olds). In the 3681 ELISA-S positive participants, ELISA-NP and SN positivity exhibited a U-shaped relationship with age, with a lower rate in 30- to 49-year-old adults, and was strongly associated with COVID-19-like symptoms. Conclusion: Our study confirms the independent role of age and symptoms on the serologic profile of anti-SARS-CoV-2 antibodies, but the non-linear relationship with age deserves further investigation.
- Subjects
FRANCE; COVID-19; SARS-CoV-2; IMMUNOGLOBULINS; AGE distribution; ENZYME-linked immunosorbent assay; DESCRIPTIVE statistics; SYMPTOMS; COVID-19 pandemic; SECONDARY analysis
- Publication
Infection, 2022, Vol 50, Issue 1, p257
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-021-01731-5