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- Title
Magnetic resonance imaging findings in patients with systemic scleroderma and musculoskeletal symptoms.
- Authors
Schanz S; Henes J; Ulmer A; Kötter I; Fierlbeck G; Claussen CD; Horger M; Schanz, Stefan; Henes, Jörg; Ulmer, Anja; Kötter, Ina; Fierlbeck, Gerhard; Claussen, C D; Horger, Marius
- Abstract
<bold>Objective: </bold>To explore the role of whole-body magnetic resonance imaging (MRI) in detecting musculoskeletal involvement in patients with systemic scleroderma and musculoskeletal symptoms.<bold>Methods: </bold>Eighteen consecutive patients (8 men, 10 women) with systemic scleroderma (median age 46 years) presenting with musculoskeletal complaints underwent whole-body MRI at 1.5 T. Images were evaluated for abnormal signal intensity and/or thickening of subcutaneous fatty tissue septa, muscular fasciae, intramuscular perifascial septa, muscle signal intensity and articular or tendon sheath synovial abnormalities on STIR and post-gadolinium scans. Additionally, C-reactive protein, creatinine kinase and the modified Rodnan skin score were determined.<bold>Results: </bold>MRI indicated evidence of fasciitis, articular synovial inflammation, and subcutaneous thickening in 16 (89 %) patients. MRI findings were compatible with myopathy or myositis in 14 (78 %) patients, tenosynovitis in 11 (61 %) patients and enthesitis in 10 (56 %) patients. Typically, these manifestations were distributed symmetrically and mostly generalised. We only found few correlations with modified Rodnan skin score, C-reactive protein and creatinine kinase.<bold>Conclusion: </bold>In patients with systemic scleroderma experiencing musculoskeletal symptoms, whole-body MRI is able to detect involvement of muscles, fasciae, joints and entheses more confidently compared with clinical and laboratory parameters.
- Publication
European Radiology, 2013, Vol 23, Issue 1, p212
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-012-2584-1