We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association between consanguineous marriages and risk of pre-eclampsia.
- Authors
Anvar, Zahra; Namavar-Jahromi, Bahia; Saadat, Mostafa
- Abstract
Purpose: The objective of this hospital-based case-control study was to assess the association between consanguinity and risk of pre-eclampsia in Shiraz (Fars Province, southern Iran) where the rate of consanguinity is relatively high. Methods: A total of 171 healthy pregnant women and 140 pre-eclamptic women were included. The healthy control group was frequency matched with the age of the pre-eclamptic women. Control women had no history of pregnancies with pre-eclampsia. Results: The prevalence of consanguinity was 42.8 and 30.9% in cases and controls, respectively. In univariate analysis, the mean inbreeding coefficient for cases (α = 0.0218) was higher than that of controls (α = 0.0174), denoting a significant difference ( p = 0.02). When family history was entered as a covariate in multivariate analysis, adjusted odds ratios (OR) revealed that the first cousin once removed (OR = 4.11, 95% CI 1.32-12.7, p = 0.014) increased the risk of pre-eclampsia, in comparison with unrelated marriages. Conclusions: Consanguinity in terms of first cousin once removed seems to be associated with pre-eclampsia after controlling for maternal age and family history of pre-eclampsia. Further investigations adjusting for other confounding factors are needed to confirm this information.
- Subjects
IRAN; CONSANGUINITY; PREECLAMPSIA; PREGNANCY complications; CASE-control method; MULTIVARIATE analysis; MATERNAL age
- Publication
Archives of Gynecology & Obstetrics, 2011, Vol 283, p5
- ISSN
0932-0067
- Publication type
Article
- DOI
10.1007/s00404-010-1528-8