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- Title
Die pathomorphologie von virusinduzierten (SV) Neoplasmen bei neugeborenen Goldhamstern.
- Authors
Bonin, O.; Unterharnscheidt, F.; Schmidt, I.; Schmidt, K.
- Abstract
The hypothesis of the viral etiology of certain neoplasms could recently be confirmed by a series of remarkable findings. It was due to the doubtlessly far reaching consequences of the detection of a tumor-producing substance in the starting material for the production of numerous vaccines (inactivated poliomyelitis-, measles- and adenovirus vaccines, attenuated poliovirus-vaccines), that the problem was examined as whether this substance may come into the vaccines or not. After the injection of suspensions of various tissue cultures into 1-day-old hamsters (cricetus auratus) sarcomas were found only in those groups of animals to which a large dose of viable SV had been administered. the rate of sarcoma incidence as well as the date of appearance depended on the dose of-SV injected. The distinct dose-dependance of the tumors induced by SV, i.e. the fact that tumors only appear after injection of high doses of virus and then only in the immediate neighbourhood of the site of injection, suggests that the development of tumors is caused or at least favoured by a local stimulating effect of the injected viral material on the tissue. The nodular neoplasms of large size (chickenegg), the morphology of which is described in detail, are polymorphic sarcomas with spindle-like and round cell formations as well as with monstrous giant cells and distinct mitotic figures The formation of capsules and the simultaneous rapid growth of the tumor account for the prolonged regressive alterations; numerous anaemic necroses are present.
- Publication
Acta Neuropathologica, 1964, Vol 3, Issue 4, p351
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/BF00691843