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- Title
Glomerular glucocorticoid receptor expression is reduced in late responders to steroids in adult-onset minimal change disease.
- Authors
Seung Hyeok Han; Sun Young Park; Jin-Ji Li; Seung Jae Kwak; Dong Sub Jung; Hoon Young Choi; Jung Eun Lee; Sung Jin Moon; Dong Ki Kim; Dae-Suk Han; Shin-Wook Kang
- Abstract
Background. Compared to children, adult patients with minimal change disease (MCD) tend to have a slower response to steroids, but little is known about the factors influencing the steroid responsiveness in these patients. In this study, we investigated the difference in the expression of the glomerular glucocorticoid receptor (GCR) according to steroid responsiveness in 28 adult-onset MCD patients. Methods. Based on the response to steroid treatment, the patients were divided into early responders (ER, n = 20) and late responders (LR, n = 8) according to the response to steroids on the basis of 4 weeks of treatment. The clinical and laboratory findings, and the glomerular mRNA and protein expression of GCR and nephrin, assessed by real-time polymerase chain reaction and immunohistochemistry, respectively, were compared between the ER and LR groups. Ten microscopic haematuric patients in whom renal biopsy was performed and revealed no histological abnormalities were included for control (C). Results. The mRNA expression of GCR was significantly lower in the LR than that in the ER group (P r = â0.49, P Conclusion. In conclusion, the levels of glomerular GCR expression may be a useful predictor of steroid responsiveness in adult-onset MCD patients.
- Subjects
GLUCOCORTICOID receptors; STEROIDS; KIDNEY diseases; NEPHROLOGY
- Publication
Nephrology Dialysis Transplantation, 2008, Vol 23, Issue 1, p169
- ISSN
0931-0509
- Publication type
Article