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- Title
Impact of weight change on albuminuria in the general population.
- Authors
Aminu K. Bello; Dick de Zeeuw; Meguid El Nahas; Auke H. Brantsma; Stephan J. L. Bakker; Paul E. de Jong; Ronald T. Gansevoort
- Abstract
Background. Increased levels of albuminuria have been recognized as a feature of obesity and the metabolic syndrome, and to be associated with an increased risk for cardiovascular and renal disease. The impact of weight change on albuminuria and its possible mechanism has not been studied yet in the general population. We investigated this issue in a cohort of the Northern European population. Methods. A total of 6894 participants of the Prevention of Renal and Vascular Endstage Disease (PREVEND) study were evaluated from baseline to a mean period of follow-up of 4.2 years for weight change (gain/loss), and its impact on albuminuria, renal function and cardiovascular risk factors. Participants were categorized into three groups based on absolute change in weight from baseline to follow-up: significant weight loss (>10âkg reduction in weight), stable weight, or significant weight gain (>10âkg increase). Multivariate regression analysis was used to evaluate the effect of baseline characteristics and time-dependent changes in these characteristics on the relationship of weight change with urine albumin excretion (UAE). Results. At follow-up 101 subjects experienced significant weight loss (mean change = â14.2âkg), 348 had significant weight gain (mean change = .4âkg) and the remaining were defined stable in weight (mean change = .4âkg). Weight loss was associated with significant improvement in systolic blood pressure (â11 ± 15âmmHg), diastolic blood pressure (â5 ± 8âmmHg), and cholesterol (â0.7 ± 1.3âmmol/l), even after adjustment for the use of medications (P P P = 0.50). Conclusion. This is the first population-based longitudinal study to show that changes in weight are associated with parallel changes in albuminuria. This relationship cannot be fully explained by the association between weight and classical cardiovascular risk factors and renal function. Based on our data we hypothesize that weight-induced changes in vascular inflammation may cause changes in albuminuria.
- Subjects
KIDNEY diseases; ALBUMINURIA; OBESITY; METABOLIC syndrome
- Publication
Nephrology Dialysis Transplantation, 2007, Vol 22, Issue 6, p1619
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/gfm091