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- Title
The use of ceftizoxime in the treatment of critically ill patients infected with multiply antibiotic resistant bacteria.
- Authors
Scully, B. E.; Neu, H. C.
- Abstract
Ceftizoxime, a β-lactamase-stable cephalosporin, was used to treat 37 patients. Twelve of 31 evaluable patients were judged to have rapidly or ultimately fatal underlying disease. Fourteen were in poor condition at the start of therapy. Twelve patients had bacteraemia; nine had pneumonia; 11 had urinary tract infection; five had intra-abdominal or soft tissue infection and two, meningitis. Sixteen of the isolates were multiresistant Gram-negative organisms. Ten of the bacteraemias were cured. These were: Streptococcus pneumoniae (3), Escherichia coli (2), Serratia marcescens (1), Klebsiella pnewnoniae (1), group G streptococci (2) and Yersinia enterocolitica (1). Two bacteraemic patients failed to respond; one had a Serratia endocarditis and the other had Enterobacter cloacae resistant to all β-lactams. All of the pneumonias responded. Ten of 11 urinary tract infections were cured. Two E. coli meningitis, one multiresistant, were cured with excellent cerebrospinal fluid levels. The overall response rate was 89%. Side effects were mild: neutropenia (1), diarrhoea (3), phlebitis (5). Ceftizoxime proved to be a useful agent in the management of these serious infections.
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1982, Vol 10, Issue suppl_C, p141
- ISSN
0305-7453
- Publication type
Article