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- Title
Pharmacokinetics of ketoconazole in normal subjects.
- Authors
Daneshmend, T. K.; Warnock, D. W.; Turner, A.; Roberts, C. J. C.; Roberts, C J
- Abstract
The serum pharmacokinetics of ketoconazole were studied in six volunteers. Each received 200 mg and 400 mg of ketoconazole as single oral doses on two occasions separated by 2 weeks. Serum ketoconazole concentrations were measured over a 48 h period using a microbiological agar diffusion method. Peak serum concentrations were proportional to dose and occurred within 3 h. The mean serum after the 200 mg dose was 122 ± 25 mm (mean ± s.o.) and after the 400 mg dose was 160 ± 29 mm. These differences were significant ( <0.01).
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 1981, Vol 8, Issue 4, p299
- ISSN
0305-7453
- Publication type
journal article