We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A semi-automated device rapidly determine circulating blood volume in healthy males and carbon monoxide uptake kinetics of arterial and venous blood.
- Authors
Breenfeldt Andersen, Andreas; Baungaard, Søren Brouw; Bejder, Jacob; Graae, Jonathan; Hristovska, Ana-Marija; Agerskov, Marianne; Holm-Sørensen, Henrik; Foss, Nicolai Bang
- Abstract
We examined whether a semi-automated carbon monoxide (CO) rebreathing method accurately detect changes in blood volume (BV) and total hemoglobin mass (tHb). Furthermore, we investigated whether a supine position with legs raised reduced systemic CO dilution time, potentially allowing a shorter rebreathing period. Nineteen young healthy males participated. BV and tHb was quantified by a 10-min CO-rebreathing period in a supine position with legs raised before and immediately after a 900 ml phlebotomy and before and after a 900 ml autologous blood reinfusion on the same day in 16 subjects. During the first CO-rebreathing, arterial and venous blood samples were drawn every 2 min during the procedure to determine systemic CO equilibrium in all subjects. Phlebotomy decreased (P < 0.001) tHb and BV by 166 ± 24 g and 931 ± 247 ml, respectively, while reinfusion increased (P < 0.001) tHb and BV by 143 ± 21 g and 862 ± 250 ml compared to before reinfusion. After reinfusion BV did not differ from baseline levels while tHb was decreased (P < 0.001) by 36 ± 21 g. Complete CO mixing was achieved within 6 min in venous and arterial blood, respectively, when compared to the 10-min sample. On an individual level, the relative accuracy after donation for tHb and BV was 102–169% and 55–165%, respectively. The applied CO-rebreathing procedure precisely detect acute BV changes with a clinically insignificant margin of error. The 10-min CO-procedure may be reduced to 6 min with no clinical effects on BV and tHb calculation. Notwithstanding, individual differences may be of concern and should be investigated further.
- Subjects
BLOOD circulation; CARBON monoxide; VEIN physiology; ARTERIAL physiology; MEN'S health; PHLEBOTOMY
- Publication
Journal of Clinical Monitoring & Computing, 2023, Vol 37, Issue 2, p437
- ISSN
1387-1307
- Publication type
Article
- DOI
10.1007/s10877-022-00921-2