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- Title
Silent echo-planar imaging for auditory FMRI.
- Authors
S. Schmitter; E. Diesch; M. Amann; A. Kroll; M. Moayer; L. Schad
- Abstract
Abstract Introduction The effect of the acoustic scanner noise produced by gradient coil switching on the auditory evoked BOLD signal represents a well-known problem in auditory functional MRI (FMRI). In this paper, a new low-noise echo-planar imaging (EPI) sequence is presented that is optimized for auditory FMRI measurements. Methods The sequence produces a narrow-band acoustic frequency spectrum by using a sinusoidal readout echo train and a constant phase encoding gradient. This narrow band is adapted to the frequency response function of the MR scanner by varying the switching frequency of the sinusoidal readout gradient. Results Compared to a manufacturer-provided standard EPI sequence, the acoustic noise reduction amounts to up to 20 dBA. Using a simple block design paradigm contrasting presentation of a pure tone during ON blocks and “silence” (absence of the tone) during OFF blocks, the new low-noise sequence was evaluated and compared to the standard EPI sequence. Statistical parametric mapping (SPM) resulted in higher levels of significance of auditory activation for the low-noise sequence. Discussion These findings strongly suggest that the low-noise sequence may generate enhanced BOLD contrasts compared to the standard EPI sequences commonly used in FMRI.
- Subjects
MAGNETIC resonance imaging; FREQUENCY response; ACOUSTIC imaging; ECHO; FREQUENCY spectra; MEDICAL imaging systems
- Publication
MAGMA: Magnetic Resonance Materials in Physics, Biology & Medicine, 2008, Vol 21, Issue 5, p317
- ISSN
0968-5243
- Publication type
Article
- DOI
10.1007/s10334-008-0132-4