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- Title
Biologically active secoiridoids: A comprehensive update.
- Authors
Peng, Zhongcan; He, Jun; Cheng, Yungchi; Xu, Jiekun; Zhang, Weiku
- Abstract
Secoiridoids are natural products of cyclopentane monoterpene derivatives that are formed by splitting the rings of cyclomethene oxime compounds at C‐7 and C‐8, and only account for a small part of cyclic ether terpenoids. Because of the chemically active hemiacetal structure in their common basic skeleton, secoiridoids have a wide range of biological activities, such as neuroprotective, anti‐inflammatory, antidiabetic, hepatoprotective, and antinociceptive activities. Phenolic secoiridoids can also act against multiple molecular targets involved in human tumorigenesis, making them potentially valuable precursors for antitumor drug development. This review provides a detailed update, covering relevant discoveries from January 2011 to December 2020, about the occurrence, structural diversity, bioactivities, and synthesis of naturally occurring secoiridoids. We aimed to resolve the lack of extensive, specific, and thorough review of secoiridoids, as well as open new areas for pharmacological investigation and better drugs based on these compounds. Highlights: 1.This review summarizes the discovery of new biological activities and mechanisms of action of secoiridoids from 2011 to 2020. We also discuss the prospects of the promising bioavailability and clinical applications of these active secoiridoids.2.More than 200 secoiridoids have been reported. More importantly, based on the existing rough category principles, we made a more systematic and detailed classification of secoiridoids and named some newly discovered structural subtypes.3.Here, we have reimagined the findings from many newly published studies and hypotheses of the classical secoiridoid biosynthesis pathway. In addition, synthetic, semisynthetic, and chemical conversion strategies for some representative compounds are discussed.
- Subjects
SECOIRIDOIDS; CYCLOPENTANE derivatives; CYCLIC ethers; DRUG target; DOSAGE forms of drugs
- Publication
Medicinal Research Reviews, 2023, Vol 43, Issue 4, p1201
- ISSN
0198-6325
- Publication type
Article
- DOI
10.1002/med.21949