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- Title
Hormone-Receptor Interactions. Demonstration of Two Message Sequences (Active Sites) in α-Melanotropin.
- Authors
Eberle, Alex; Schwyzer, Robert
- Abstract
The purpose of this investigation was to elucidate the biological significance of the tripeptide sequence 11-13, -Lys-Pro-Val · NH2 contained in α-melanocyte-stimulating hormone. To this end the in vitro melanotropic activities of 21 synthetic peptides related to the hormone were determined and compared with one-another and with results reported in the literature. The tripeptide amide, H · Lys-Pro-Val · NH2, its Nα-acetylderivative, and -weakly, but distinctly-Nα-acetyl-L-lysine-amide were found to be hormonally active. The following conclusions were drawn: (1) α-melanophore-stimulating hormone possesses two message sequences (active sites), -Met-Glu-His-Phe-Arg-Trp-Gly-, and -Lys-Pro-Val · NH2 which are capable of independently triggering the hormone receptor responsible for melanin dispersion. (2) In correct covalent combination, the two message sequences act in a 'cooperative' manner to potentiate their activities on the receptors. (3) -Lys-Pro-Val- is an address sequence in adrenocorticotropic hormone and a message sequence in α-melanocyte-stimulating hormone. This implies that the two receptors (adrenal and melanocyte), albeit recognizing -Met-Glu-His-Phe-Arg-Trp-Gly- as stimulus, differ fundamentally in their response to -Lys-Pro-Val-.
- Publication
Helvetica Chimica Acta, 1975, Vol 58, Issue 6, p1528
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/hlca.19750580604