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- Title
AVALIAÇÃO DA ATIVIDADE ANTIFÚNGICA DE SAPIUM HAEMATOSPERMUM SOBRE Candida parapsilosis.
- Authors
Rabelo Parreira, Jade; de Sousa Oliveira Balestra, Amanda Fernandes; Pascoal Teles, Flávia; Silva Andrade, Letícia; Ribeiro de Resende, Nathália Kriss; de Sousa Fontoura, Humberto
- Abstract
INTRODUCTION Candidiasis is a fungal infection of great medical importance, especially by Candida albicans, which is one of the most common etiological agents. However, episodes of candidiasis have emerged by other species, such as Candida parapsilosis. Sapium haematospermum, known as a milkwood, is a tree with extensive Brazilian geographic distribution and has been studied for its anti-inflammatory capacity and potential antifungal activity. Even with the therapeutic measures currently used, there is a limited number of antifungal agents available and increased resistance to them, increasing the demand for new treatment alternatives. OBJECTIVE In this perspective, the present work aims to analyze the antifungal activity of S. haematospermum on C. parapsilosis. METHODOLOGY For this, a quantitative experimental study was carried out, carried out in the laboratory by preparing the extracts of S. haematospermum and the cultivation and maintenance of the fungus of the C. parapsilosis strain under specific conditions. Subsequently, tests such as plate sensitivity, synergism and diffusion disc sensitivity were applied. RESULTS AND DISCUSSION The results show that the presence of S. haematospermum water extract, at different concentrations, was not able to inhibit the growth of C. parapsilosis. However, synergistic activity was observed between leaf and fluconazole, as well as sensitivity, demonstrated by the formation of inhibition halos. CONCLUSION It is concluded that the extract of S. haematospermum does not present antifungal activity on C. parapsilosis in a dose-dependent manner, but has synergistic activity with fluconazole, so that fungal cells grow and form colonies with difficulty.
- Subjects
MYCOSES; CANDIDA albicans; CANDIDIASIS; FLUCONAZOLE; CANDIDA
- Publication
Revista Foco (Interdisciplinary Studies Journal), 2024, Vol 17, Issue 5, p1
- ISSN
1981-223X
- Publication type
Article
- DOI
10.54751/revistafoco.v17n5-083