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- Title
Non-Coding RNAs: Strategy for Viruses’ Offensive.
- Authors
Gallo, Alessia; Bulati, Matteo; Miceli, Vitale; Amodio, Nicola; Conaldi, Pier Giulio
- Abstract
The awareness of viruses as a constant threat for human public health is a matter of fact and in this resides the need of understanding the mechanisms they use to trick the host. Viral non-coding RNAs are gaining much value and interest for the potential impact played in host gene regulation, acting as fine tuners of host cellular defense mechanisms. The implicit importance of v-ncRNAs resides first in the limited genomes size of viruses carrying only strictly necessary genomic sequences. The other crucial and appealing characteristic of v-ncRNAs is the non-immunogenicity, making them the perfect expedient to be used in the never-ending virus-host war. In this review, we wish to examine how DNA and RNA viruses have evolved a common strategy and which the crucial host pathways are targeted through v-ncRNAs in order to grant and facilitate their life cycle.
- Subjects
NON-coding RNA; RNA viruses; GENETIC regulation; VIRAL genomes; DNA viruses
- Publication
Non-Coding RNA, 2020, Vol 6, Issue 3, p1
- ISSN
2311-553X
- Publication type
Article
- DOI
10.3390/ncrna6030038