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- Title
Endometrial adenosquamous carcinoma with osteoclast-like giant cells: immunohistochemistry and histogenesis.
- Authors
Imura, Johji; Tomita, Shigeki; Ono, Yuko; Inaba, Fujiyuki; Yamazaki, Tatsuo; Fukasawa, Ichio; Inaba, Noriyuki; Fujimori, Takahiro
- Abstract
Imura J, Tomita S, Ono Y, Inaba F, Yamazaki T, Fukasawa I, Inaba N, Fujimori T. Endometrial adenosquamous carcinoma with osteoclast-like giant cells: immunohistochemistry and histogenesis. APMIS 2005;113:140–4.Primary extraskeletal epithelial neoplasms containing osteoclast-like giant cells (OGCs) are rare. We herein describe a case of adenosquamous carcinoma that developed in the endometrium together with non-neoplastic OGCs. The patient was a 72-year-old woman who underwent radical hysterectomy with salpingo-oophorectomy and lymph node dissection after being diagnosed with uterine cancer. Histologically, the tumor was found to be an adenosquamous carcinoma containing a large number of OGCs and mononuclear cells (MNCs) that had infiltrated into the stroma. Immunohistochemically, the OGCs and MNCs stained strongly positive for KP-1 and alpha-1-antichymotrypsin, and negative for the epithelial markers epithelial membrane antigen (EMA) and cytokeratins. These findings suggest that the OGCs and MNCs in this patient's tumor originated from monocytes/histiocytes, and most likely developed as part of the stromal reaction to the neoplasm.
- Subjects
CELLS; IMMUNOHISTOCHEMISTRY; OSTEOCLASTS; ENDOMETRIUM; PATHOLOGY
- Publication
APMIS, 2005, Vol 113, Issue 2, p140
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/j.1600-0463.2005.apm1130208.x