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- Title
Intraosseous epithelioid malignant peripheral nerve sheath tumor of the phalanx.
- Authors
HIROKAWA, MITSUYOSHI; SHIMIZU, MICHIO; FUKUOKA, KEIKO; TORIGOE, NOBUYUKI; HINO, YOSUKE; MIKAWA, YOSHIHIRO; MANABE, TOSHIAKI
- Abstract
We report the first case of intraosseous epithelioid malignant peripheral nerve sheath tumor (MPNST) occurring in the phalanx. The patient was a 50-year-old Japanese man with an intramedullary lytic lesion of the proximal phalanx. Microscopically, the tumor was composed of epithelioid cells or polygonal cells, forming large cell nests with central necrosis. Most tumor cells were diffusely and strongly immunopositive for S-100 protein and vimentin, and negative for cytokeratin, epithelial membrane antigen, carcinoembryonic antigen, alpha-smooth muscle actin, and HMB-45. Laminin-positive material was discontinuously demonstrated between the individual tumor cells. Electron microscopy showed prominent external lamina. Our case indicated that laminin is useful for differentiating epithelioid MPNST from metastatic carcinoma and malignant melanoma.
- Publication
APMIS, 1999, Vol 107, Issue 1-6, p401
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/j.1699-0463.1999.tb01572.x