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- Title
LAT regulates ?d T cell homeostasis and differentiation.
- Authors
Nuñez-Cruz, Selene; Aguado, Enrique; Richelme, Sylvie; Chetaille, Bruno; Mura, Anne-Marie; Richelme, Mireille; Pouyet, Laurent; Jouvin-Marche, Evelyne; Xerri, Luc; Malissen, Bernard; Malissen, Marie
- Abstract
LAT (linker for activation of T cells) is essential for T cell receptor signaling. Mice homozygous for a mutation of the three C-terminal LAT tyrosine residues showed a block in aß T cell development and a partially impaired ?d T cell development. Without intentional immunization, they accumulated ?d T cells in the spleen and lymph nodes that chronically produced T helper type 2 cytokines in large amounts, and caused the maturation of plasma cells secreting immunoglobulin E (IgE) and IgG1. These effects are very similar to that triggered in the aß lineage by a mutation involving a distinct LAT tyrosine. Thus, LAT is an essential regulator of T cell homeostasis and terminal differentiation.
- Subjects
T cell receptors; IMMUNIZATION; HOMEOSTASIS; CELL differentiation; TYROSINE
- Publication
Nature Immunology, 2003, Vol 4, Issue 10, p999
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni977