We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
New principles of treatments in malignant diseases.
- Authors
Udriștioiu, Aurelian; Badea, Delia Nica
- Abstract
B-cell chronic lymphocytic leukaemia (B-CLL) is one of the most common hematologic malignant diseases with high prevalence in elderly. Although the pathological entity is studied for decades, CLL remains an incurable disease in patients who require therapeutic intervention in different stages of disease. Overexpression of the B cell receptor, (BCR) on the cell surface of malignant B cells expresses a variety of specific surface antigens which could theoretically act as targets for the chimeric antigen receptor (CD5, CD 20, CD38, CD40 and CD44). Activated T cells were identified with membrane T receptors (TCR), CD7, CD5, CD3, CD2, CD4, CD8 CD 28, CD45-RO and CD73. The B and T cell activation leads to glucose stability but mutant P-53 gene promotes cancer cells growth and generates a positive regulatory loop. The frequencies of P-53 gene mutations and its deletion in CLL can be categorized as individual biomarkers in proteomic and genomic profile for this type of leukaemia that can be implemented for treatment of targeted patient of personalized medicine and palliative chemotherapies.
- Subjects
CANCER cells; DISEASE progression
- Publication
Paliatia: Journal of Palliative Care, 2018, Vol 11, Issue 1, p6
- ISSN
1844-7058
- Publication type
Article