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- Title
妊娠高血压视网膜病变影响因素分析及血管内皮功能检测的临床意义.
- Authors
陈艺中; 罗红; 袁昌亮; 王苏; 陈岚
- Abstract
Object: To investigate the influencing factors of retinopathy in pregnancy-induced hypertension and the clinical significance of the detection of vascular endothelial function. Methods; 150 patients with hypertensive retinopathy of pregnancy who were admitted to Maternal and Child Health Hospital of Hubei Province from January 2017 to December 2018 were prospectively selected as observation group. According to the international standard of Duker-Elder fundus staging, they were divided into phase I group (69 cases), phase II group (57 cases) and phase III group (24 cases). 40 patients with pregnancy-induced hypertension without retinopathy who were admitted to the hospital during the same period were selected as the control group. The serum levels of insulin-like growth factor-1 (IGF-1) and endothelin-1 (ET-1) were detected by enzyme-linked immunosorbent assay, The correlation between the levels of IGF-1 and ET-1 and the severity of retinopathy were analyzed by Pearson correlation analysis, and the influencing factors of retinopathy in pregnancy-induced hypertension were analyzed by multivariate logistic regression. Results: With the increase of Duker-Elder's fundus staging, the level of serum ET-1 increased, and the level of serum IGF-1 decreased (P<0.05). Pearson correlation analysis showed that the severity of lesion was negatively correlated with level of serum IGF-1, but it was positively correlated with level of serum ET-1 (P<0.05). Univariate analysis showed that the incidence of retinopathy in pregnancy-induced hypertension were related to course of disease, gestational age, blood pressure, body mass, proteinuria and hematocrit (P<0.05), and it was not related with age (P>0.05). Logistic regression analysis showed that Course of disease>3W, blood pressure>160/110 mmHg, body weight >85 kg, proteinuria +++, hematocrit>0.35 were all independent risk factors for retinopathy of pregnancy-induced hypertension (P<0.05), while gestational age>28W was the protective factor (P<0.05). Conclusion: There are abnormal expressions of IGF-1 and ET-1 in patients with pregnancy-induced hypertensive retinopathy, and the expression level is closely related to the degree of retinopathy. The blood pressure, course of disease, proteinuria, body weight and hematocrit are the main risk factors for the occurrence of pregnancy-induced hypertension retinopathy, and the gestational age is the protective factor.
- Subjects
HYPERTENSION; ENZYME-linked immunosorbent assay; BLOOD pressure; LOGISTIC regression analysis; GESTATIONAL age
- Publication
Progress in Modern Biomedicine, 2020, Vol 20, Issue 2, p319
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2020.02.024