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- Title
地屈孕酮联合环孢素A 治疗原因不明复发性流产的效果观察.
- Authors
郭娜; 刘丹; 王婷; 王艳霞; 米阳
- Abstract
Objective: To explore the clinical effect of dydrogesterone combined with CsA in the treatment of unexplained recurrent abortion. Methods: 81 cases of unexplained recurrent abortion diagnosed and treated in our hospital from May 2015 to June 2018 were selected, which were divided into two groups according to the sequence of admission. 40 cases of the control group were treated with dydrogesterone, while 41 cases of the observation group were treated with CsA on the basis of the control group. The pregnancy success rate and pregnancy outcome of the two groups were compared, and the levels of serum β-HCG, P and E2 were compared between the two groups at 8 and 10 weeks of gestation, and T, B and NK lymphocyte before pregnancy were compared between the two groups. Results: The success rate of pregnancy in the observation group was 87.8%, which was significantly higher than that of the control group (67.5%, P<0.05). But there was no significant difference in the preterm birth or gestational week between the two groups after successful pregnancy (P>0.05). At 8 weeks and 10 weeks of gestation, the levels of serum β-HCG and E2 in the observation group was significantly higher than that in the control group (P>0.05). While there was no significant difference in serum P level between the two groups(P>0.05). The levels of CD4+, CD4+/CD8+ and NK cells pre-pregnancy in the observation group were significantly lower than those in the control group, and the levels of CD8+ were significantly higher than those in the control group(P>0.05). But there was no statistical difference between the two groups about CD3+ and B cell level (P>0.05). Conclusion: Dydrogesterone combined with CsA can improve the level of serum β-HCG and E2 in early pregnancy of patients with unexplained recurrent abortion, inhibit the immune function of patients in active state, and thus improve the success rate of pregnancy without affecting the pregnancy outcome, which is worthy of clinical reference.
- Subjects
KILLER cells; B cells; PREMATURE labor; PREGNANCY; CONTROL groups; LYMPHOCYTE count
- Publication
Progress in Modern Biomedicine, 2019, Vol 19, Issue 15, p2929
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2019.15.029