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- Title
Nuclear Positioning Requires a Tug-of-War between Kinesin Motors.
- Authors
Augustine, Robert C.
- Abstract
Surprisingly, rescue experiments showed that the KCH calponin homology domain - an actin binding surface assumed to mediate crosstalk between the MT and actin cytoskeletons - is dispensable for both nuclear positioning and tip growth. While the plant kinesin-14s are prime candidates to substitute for dynein function, elucidating their function has been inherently complicated by gene redundancy, especially within the Kinesin with Calponin Homology domain (KCH) subclade. Thus, it appears that KCH kinesins share at least some attributes with dynein, including the processive, retrograde delivery of cargo along MTs.
- Subjects
KINESIN; MOLECULAR motor proteins; CELL motility; CELL physiology; SPINDLE apparatus; MICROTUBULES; CYTOSKELETON
- Publication
Plant Cell, 2018, Vol 30, Issue 7, p1383
- ISSN
1040-4651
- Publication type
Article
- DOI
10.1105/tpc.18.00499