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- Title
A case of pernicious anemia requiring differential diagnosis of autoimmune hemolytic anemia complication.
- Authors
Saki Todo; Kohei Okamoto; Takeshi Sugimoto; Toshimasa Takahashi; Yasushi Nakagawa; Takashi Arai; Katsuhito Nishiyama; Kenta Hara; Yoshiro Yasutomo; Koichi Yokono
- Abstract
An 80-year-old female was admitted to our hospital due to malaise. The initial diagnosis on admission was pernicious anemia (PA), Hashimoto thyroiditis and autoimmune atrophic gastritis. Autoimmune hemolytic anemia was suspected because direct antiglobulin test (DAT) was positive. Treatment with vitamin B12 improved anemia, with the disappearance of hemolysis. In some cases, PA patients with positive DAT may have hemolysis without the involvement of the autoimmune mechanism. Therefore, it is important to carefully assess PA patients with hemolysis and positive DAT for the prevention of unnecessary administration of steroid therapy.
- Subjects
PERNICIOUS anemia; DIRECT Coombs' test; AUTOIMMUNE diseases
- Publication
Oxford Medical Case Reports, 2017, Vol 2017, Issue 9, p172
- ISSN
2053-8855
- Publication type
Case Study
- DOI
10.1093/omcr/omx053