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- Title
Recurrence of herpes simplex encephalitis associated with temozolomide chemoradiation for malignant glioma: a case report and review of the literature.
- Authors
Christman, Mitalee P.; Turbett, Sarah E.; Sengupta, Soma; Bakhadirov, Khamidulla U.; Williamson, Craig A.; Nayak, Lakshmi; Milligan, Tracey; Katz, Joel T.
- Abstract
Although herpes simplex encephalitis is not classically considered an opportunistic infection, reactivation of herpes simplex is being seen increasingly in patients with cancer or immunosuppression. The authors present a patient with malignant glioma and HSV-1 encephalitis whose PCR-proven encephalitis recurred after temozolomide (TMZ) chemoradiation despite acyclovir therapy, and summarize details of four other cases of HSV-1 encephalitis associated with TMZ. The similarity among these cases raises the likely need for longer treatment courses and/or oral suppressive therapy in patients at risk for herpes simplex infections who are receiving TMZ.
- Subjects
HERPES simplex; TEMOZOLOMIDE; GLIOMAS; IMMUNOSUPPRESSION; CANCER chemotherapy; PATIENTS; DIAGNOSIS
- Publication
Oxford Medical Case Reports, 2014, Vol 2014, Issue 1, p1
- ISSN
2053-8855
- Publication type
Case Study
- DOI
10.1093/omcr/omu001