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- Title
CC Chemokine Ligand 18 Correlates with Malignant Progression of Prostate Cancer.
- Authors
Guo Chen; Yu-xiang Liang; Jian-guo Zhu; Xin Fu; Yan-fei Chen; Ru-jun Mo; Liang Zhou; Hao Fu; Xue-cheng Bi; Hui-chan He; Sheng-bang Yang; Yong-ding Wu; Fu-neng Jiang; Wei-de Zhong
- Abstract
Background and Aim. CC chemokine ligand 18 (CCL18) promotes malignant behaviors of various human cancer types. However, its involvement in human prostate cancer has not been fully elucidated. The aimof this studywas to investigate the role of CCL18 in PCa. Methods. Expression ofCCL18 atmRNAand protein levels was detected using real-time qRT-PCR and immunohistochemistry analysis. We analyzed the associations of CCL18 expression with clinical features of human PCa. The effects of PCa cell migration, invasion, and apoptosis were tested. The efficiency of CCL18 on prostate tumor growth was assessed in a subcutaneous xenograft model. Results. CCL18 expression was upregulated (both P < 0.01) in PCa tissues compared with those in noncancerous prostate tissues. CCL18 upregulation was correlated with high Gleason score (P = 0.034) of patients with PCa. rCCL18 stimulation in PCa cells promoted cell migration and invasion but decreased DU145 cells apoptosis rate. Furthermore, subcutaneous homografts models showed the increased tumor growth and tumor vascularization with the CCL18 stimulation, and the expression of Ki67, PCNA, and CD31 in CCL18 stimulation mice was also significantly increased. Conclusions. Our data offer the convincing evidence that the upregulation of CCL18 may be involved in the malignant progression of PCa.
- Publication
BioMed Research International, 2014, Vol 2014, p1
- ISSN
2314-6133
- Publication type
Article
- DOI
10.1155/2014/230183