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- Title
A sensitive chemotaxis assay using a novel microfluidic device.
- Authors
Zhang, Chen; Jang, Sunyoung; Amadi, Ovid C; Shimizu, Koichi; Lee, Richard T; Mitchell, Richard N
- Abstract
Existing chemotaxis assays do not generate stable chemotactic gradients and thus--over time--functionally measure only nonspecific random motion (chemokinesis). In comparison, microfluidic technology has the capacity to generate a tightly controlled microenvironment that can be stably maintained for extended periods of time and is, therefore, amenable to adaptation for assaying chemotaxis. We describe here a novel microfluidic device for sensitive assay of cellular migration and show its application for evaluating the chemotaxis of smooth muscle cells in a chemokine gradient.
- Publication
BioMed Research International, 2013, Vol 2013, p373569
- ISSN
2314-6133
- Publication type
Journal Article
- DOI
2013/373569