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- Title
Quantifying airway remodelling for research or clinical purposes: How should we normalize for airway size?
- Authors
Donovan, Graham M.; Wang, Kimberley C. W.; Elliot, John G.; James, Alan L.; Noble, Peter B.
- Abstract
Keywords: asthma; pathology; respiratory structure and function EN asthma pathology respiratory structure and function 223 225 3 02/21/23 20230301 NES 230301 Key points Measurements of airway wall dimensions are normalized to perimeter of basement membrane (P SB bm sb ) that is, airway size. Both this approach, and a simple ASM/P SB bm sb ratio, can be thought of as special cases of assuming that ASM is related to P SB bm sb SP a sp by a so-called I power law i , where HT <math display="inline" overflow="scroll" altimg="urn:x-wiley:13237799:media:resp14454:resp14454-math-0002" xmlns="http://www.w3.org/1998/Math/MathML"><mi mathvariant="italic">ASM</mi><mo> </mo><msubsup><mi>P</mi><mi mathvariant="italic">bm</mi><mi>a</mi></msubsup></math> ht for some constant ' I a i '. Take ASM for example, which has a power law exponent slightly above 1.0 just before birth, rising throughout early childhood to a value of approximately 1.8 in a non-asthma adult population; the exponent in fatal asthma is higher still, approaching 2 (Figure 1C).
- Subjects
AIRWAY (Anatomy); MEDICAL research
- Publication
Respirology, 2023, Vol 28, Issue 3, p223
- ISSN
1323-7799
- Publication type
Article
- DOI
10.1111/resp.14454