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- Title
Genetic Diversity of Serine Protease Inhibitors in Myxozoan (Cnidaria, Myxozoa) Fish Parasites.
- Authors
Eszterbauer, Edit; Sipos, Dóra; Kaján, Győző L.; Szegő, Dóra; Fiala, Ivan; Holzer, Astrid S.; Bartošová-Sojková, Pavla
- Abstract
We studied the genetic variability of serine protease inhibitors (serpins) of Myxozoa, microscopic endoparasites of fish. Myxozoans affect the health of both farmed and wild fish populations, causing diseases and mortalities. Despite their global impact, no effective protection exists against these parasites. Serpins were reported as important factors for host invasion and immune evasion, and as promising targets for the development of antiparasitic therapies. For the first time, we identified and aligned serpin sequences from high throughput sequencing datasets of ten myxozoan species, and analyzed 146 serpins from this parasite group together with those of other taxa phylogenetically, to explore their relationship and origins. High intra- and interspecific variability was detected among the examined serpins. The average sequence identity was 25–30% only. The conserved domains (i.e., motif and signature) showed taxon-level differences. Serpins clustered according to taxonomy rather than to serpin types, and myxozoan serpins seemed to be highly divergent from that of other taxa. None of them clustered with their closest relative free-living cnidarians. The genetic distinction of myxozoan serpins further strengthens the idea of an independent origin of Myxozoa, and may indicate novel protein functions potentially related to parasitism in this animal group.
- Subjects
PROTEASE inhibitors; FISH parasites; MYXOZOA; CNIDARIA; SERPINS; SERINE
- Publication
Microorganisms, 2020, Vol 8, Issue 10, p1502
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms8101502