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- Title
Circular RNA hsa_circ_0051040 Promotes Hepatocellular Carcinoma Progression by Sponging miR-569 and Regulating ITGAV Expression.
- Authors
Ju, Linling; Yao, Min; Lu, Rujian; Cao, Yali; Wang, Huixuan; Yuan, Liuxia; Xiao, Feng; Shao, Jianguo; Cai, Weihua; Chen, Lin; Bian, Zhaolian
- Abstract
Accumulating evidence has demonstrated the roles of circular RNAs (circRNAs) in hepatocellular carcinoma (HCC); however, their roles in HCC need to be further studied. Through high-throughput human circRNA microarray analysis of HCC and adjacent normal tissues, we identified hsa_circ_0051040 as a novel candidate circRNA for the diagnosis and treatment of HCC. In this study, we found that hsa_circ_0051040 was overexpressed in HCC tissues and cell lines and that its expression was correlated with poor prognosis. Knockdown of hsa_circ_0051040 inhibited the migration, invasion, and proliferation of HCC cells in vitro and in vivo, whereas overexpression of hsa_circ_0051040 had the opposite effects. Moreover, our data demonstrated that hsa_circ_0051040 acted as a sponge for miR-569 to regulate ITGAV expression and induce EMT progression. Our findings indicated that hsa_circ_0051040 promotes HCC development and progression by sponging miR-569 to increase ITGAV expression. Thus, hsa_circ_0051040 is a good candidate as a therapeutic target.
- Subjects
CIRCULAR RNA; GENE expression; HEPATOCELLULAR carcinoma; CELL proliferation; CELL lines; GENETIC overexpression
- Publication
Cells (2073-4409), 2022, Vol 11, Issue 22, p3571
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells11223571