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- Title
Anti-cN1A Antibodies Are Associated with More Severe Dysphagia in Sporadic Inclusion Body Myositis.
- Authors
Lucchini, Matteo; Maggi, Lorenzo; Pegoraro, Elena; Filosto, Massimiliano; Rodolico, Carmelo; Antonini, Giovanni; Garibaldi, Matteo; Valentino, Maria Lucia; Siciliano, Gabriele; Tasca, Giorgio; De Arcangelis, Valeria; De Fino, Chiara; Mirabella, Massimiliano; Deschenes, Michael
- Abstract
In recent years, an autoantibody directed against the 5′-citosolic nucleotidase1A (cN1A) was identified in the sera of sporadic inclusion body myositis (s-IBM) patients with widely variable sensitivity (33%–76%) and specificity (87%–100%). We assessed the sensitivity/specificity of anti-cN1A antibodies in an Italian cohort of s-IBM patients, searching for a potential correlation with clinical data. We collected clinical data and sera from 62 consecutive s-IBM patients and 62 other inflammatory myopathies patients. Testing for anti-cN1A antibodies was performed using a commercial ELISA. Anti-cN1A antibodies were detected in 23 s-IBM patients, resulting in a sensitivity of 37.1% with a specificity of 96.8%. Positive and negative predictive values were 92.0% and 60.6%, respectively. We did not find significant difference regarding demographic variables, nor quadriceps or finger flexor weakness. Nevertheless, we found that anti-cN1A-positive patients presented significantly lower scores in IBMFRS item 1 (swallowing, p = 0.045) and more frequently reported more severe swallowing problems, expressed as an IBMFRS item 1 score ≤ 2 (p < 0.001). We confirmed the low sensitivity and high specificity of anti-cN1A Ab in s-IBM patients with a high positive predictive value. The presence of anti-CN1A antibodies identified patients with a greater risk of more severe dysphagia.
- Subjects
INCLUSION body myositis; MYOSITIS; DEGLUTITION; IMMUNOGLOBULINS; DEGLUTITION disorders; ANTIBODY titer
- Publication
Cells (2073-4409), 2021, Vol 10, Issue 5, p1146
- ISSN
2073-4409
- Publication type
Article
- DOI
10.3390/cells10051146