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- Title
Exploiting the Achilles’ heel of cancer: disrupting glutamine metabolism for effective cancer treatment.
- Authors
Yuxin Fan; Han Xue; Zhimin Li; Mingge Huo; Hongxia Gao; Xingang Guan
- Abstract
Cancer cells have adapted to rapid tumor growth and evade immune attack by reprogramming their metabolic pathways. Glutamine is an important nitrogen resource for synthesizing amino acids and nucleotides and an important carbon source in the tricarboxylic acid (TCA) cycle and lipid biosynthesis pathway. In this review, we summarize the significant role of glutamine metabolism in tumor development and highlight the vulnerabilities of targeting glutamine metabolism for effective therapy. In particular, we review the reported drugs targeting glutaminase and glutamine uptake for efficient cancer treatment. Moreover, we discuss the current clinical test about targeting glutamine metabolism and the prospective direction of drug development.
- Subjects
GLUTAMINE; CANCER treatment; TRICARBOXYLIC acids; AMINO acids; DRUG development; TUMOR growth
- Publication
Frontiers in Pharmacology, 2024, p1
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2024.1345522