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- Title
Role of type I interferons in inflammasome activation, cell death, and disease during microbial infection.
- Authors
Subbarao Malireddi, R. K.; Kanneganti, Thirumala-Devi
- Abstract
Interferons (IFNs) were discovered over a half-century ago as antiviral factors. The role of type I IFNs has been studied in the pathogenesis of both acute and chronic microbial infections. Deregulated type I IFN production results in a damaging cascade of cell death, inflammation, and immunological host responses that can lead to tissue injury and disease progression. Here, we summarize the role of type I IFNs in the regulation of cell death and disease during different microbial infections, ranging from viruses and bacteria to fungal pathogens. Understanding the specific mechanisms driving type I IFN-mediated cell death and disease could aid in the development of targeted therapies.
- Subjects
INTERFERONS; INFLAMMATION; CELL death; COMMUNICABLE diseases; ANTIVIRAL agents; IMMUNE response; DISEASE progression
- Publication
Frontiers in Cellular & Infection Microbiology, 2013, Vol 3, p1
- ISSN
2235-2988
- Publication type
Article
- DOI
10.3389/fcimb.2013.00077