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- Title
Omega‐3 as an adjuvant in the treatment eating and psychological symptoms in patients with anorexia nervosa: a systematic review and meta‐analyses.
- Authors
Candido, Ana Claudia Rodrigues; Ferraz, Sarah Dagostin; Uggioni, Maria Laura Rodrigues; Zanevan, Ivan Rosso; Colonetti, Laura; Grande, Antônio José; Colonetti, Tamy; Rosa, Maria Inês da
- Abstract
Background: This study was carried out to assess the effects of omega‐3 supplementation as an adjunct treatment for eating and psychological symptoms in patients with anorexia nervosa. Methods: We conducted a systematic review of the literature using the terms 'anorexia nervosa' AND 'Fatty Acids, Omega‐3'. Five randomised controlled trials with a total of 144 participants, published between 2003 and 2022, were included. Results: The effects of supplementation of omega‐3 on anxiety were standardised mean difference (SMD) 0.79, 95% confidence interval (CI) −0.08 to 1.66; p = 0.08; I² = 3%; two studies, 33 participants; moderate quality of evidence. For depression, the supplementation of omega‐3 was SMD: 0.22, 95% CI: −0.50 to 0.93; p = 0.18; I² = 45%; two studies, 33 participants; moderate quality of evidence. For obsessive‐compulsive disorder, the supplementation of omega‐3 was SMD: −0.22, 95% CI: −0.70 to 2.25; p = 0.36; I² = 0%; three studies, 32 participants; low quality of evidence. Conclusion: This research showed that regardless of dose, time or, if associated with other components, the use of omega‐3 supplementations as an adjuvant treatment showed no evidence of effect in eating and psychological symptoms in patients with anorexia nervosa. Key points: The treatment of anorexia nervosa patients is complex and requires a multidisciplinary team because, in addition to nutritional symptoms, psychiatric symptomatologies such as depression, anxiety or obsessive‐compulsive disorder are common comorbidities.Anorexia nervosa, depression, anxiety and obsessive‐compulsive disorder are mediated by inflammatory markers whose synthesis is inhibited by the action of omega‐3.The omega‐3 supplementation as an adjuvant treatment showed no evidence of effect in eating and psychological symptoms in patients with anorexia nervosa.
- Subjects
META-analysis; CONFIDENCE intervals; SYSTEMATIC reviews; DIETARY supplements; TREATMENT effectiveness; OMEGA-3 fatty acids; DESCRIPTIVE statistics; ANOREXIA nervosa; PSYCHOLOGICAL stress; EVALUATION
- Publication
Journal of Human Nutrition & Dietetics, 2023, Vol 36, Issue 5, p1970
- ISSN
0952-3871
- Publication type
Article
- DOI
10.1111/jhn.13187