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- Title
Gastric emptying is slower in women than men with type 2 diabetes and impacts on postprandial glycaemia.
- Authors
Xiang, Chunjie; Sun, Yixuan; Luo, Yong; Xie, Cong; Huang, Weikun; Jones, Karen L.; Horowitz, Michael; Sun, Zilin; Rayner, Christopher K.; Ma, Jianhua; Wu, Tongzhi
- Abstract
Aim: To evaluate sex differences in gastric emptying and the glycaemic response to a glucose drink and a high carbohydrate meal in type 2 diabetes (T2D). Methods: In cohort 1, 70 newly diagnosed, treatment‐naïve Chinese patients with T2D (44 men) recruited from a diabetes outpatient clinic ingested a 75‐g glucose drink containing 150 mg 13C‐acetate. In cohort 2, 101 Australian patients with T2D (67 male) recruited from the community, managed by diet and/or metformin monotherapy, ingested a semi‐solid mashed potato meal, labelled with 100 μl 13C‐octanoic acid. Breath samples were collected over 3 and 4 h, respectively, for assessment of gastric emptying, and venous blood was sampled for evaluation of glycaemia (with and without adjustment for each participant's estimated total blood volume). Results: Gastric emptying was slower in female than male subjects in both cohorts (both p <.01). Multiple linear regression analyses revealed that gastric emptying was independently associated with sex (both p <.05). Without adjustment for blood volume, the glycaemic responses to oral glucose and the mixed meal were greater in female subjects (both p <.001). However, after adjustment for blood volume, the glycaemic responses were greater in men (both p <.05). Conclusions: Gastric emptying is slower in women than men with T2D, associated with a reduced blood volume‐adjusted glycaemic response to oral glucose and a mixed meal in women. These observations highlight the sex difference in postprandial glucose handling, which is relevant to the personalized management of postprandial glycaemia in T2D.
- Subjects
GASTRIC emptying; TYPE 2 diabetes; BLOOD volume; MULTIPLE regression analysis; CHINESE people
- Publication
Diabetes, Obesity & Metabolism, 2024, Vol 26, Issue 8, p3119
- ISSN
1462-8902
- Publication type
Article
- DOI
10.1111/dom.15635